Kriya Shakti Foundation
Kriya Shakti means “the power of action”—the energy to create change. In our daughter Kriya, we see that spark every day. She lives with an exceedingly rare condition caused by an ARID5B exon 10 mutation, and there is no cure and very little research to turn to. She is not alone. For these children, every day matters. We are acting now to fund research for Kriya and for every child affected by ARID5B Exon 10 mutation
Why Your Support Matters
Every dollar raised through Kriya Shakti goes directly toward moving the needle toward a cure.
ARID5B-related neurodevelopmental disorder is a rare genetic condition first formally described in 2026. It is caused by changes in the ARID5B gene, which helps control how other genes switch on during early development. Most affected individuals—including our daughter, Kriya—carry a truncating variant in the gene’s long final exon (exon 10). This variant traps the ARID5B protein outside the cell nucleus, preventing it from doing its job.
People living with this condition typically experience developmental delays, speech and language challenges, and learning differences. Many also face attention and behavioral differences, low muscle tone, feeding difficulties, kidney and urinary tract abnormalities, and recurrent infections. In some cases, individuals experience serious inflammatory episodes affecting the brain.
We are raising funds to:
• Fuel Rare Disease Research: Support geneticists, cellular biologists, and laboratories dedicated to mapping the exact pathways of ARID5B exon 10 variants.
• Develop Medical Models: Fund the creation of cellular and specialized models, such as CRISPR knock-in designs, needed to test potential treatments.
• Pave the Way for Gene Therapy: Drive early-stage research into how the shortened protein can be corrected, overridden, or safely managed inside the cell.
Our daughter's name means action, and her shakti is the strength of the community rallying behind her. Right now, we know the name and face of only one child living with this condition. However, we know this research will matter deeply to the few others already diagnosed and the many more still waiting for answers.
By donating, you aren't just helping Kriya—you are becoming a foundational pioneer in unlocking the science to cure ARID5B mutations. Thank you for standing with us, believing in science, and helping build a brighter, cured tomorrow for the entire ARID5B Exon 10 community. Learn more at https://www.arid5bneuroresearch.org/